Hop extract, is the extract of hops which in turn are the dried, flowering parts of the hops plant (Humulus lupulus). This plant is twining vine that is native to Eurasia and temperate regions of North America.
Ingredients A-Z
Inositol
Overview
This plant has been commonly used for brewing beer and as food flavouring. Besides that, it is also believed that hop extract might offer health benefits such as anti-inflammation, anti-anxiety, pain-relieving and even anti-cancer.
Key indications
Insomnia
Study shows that taking hop extract combined with valerian root extract is beneficial in patients with insomnia. By taking two tablets of a combination containing 83.8mg hop extract and 374mg valerian root extract every night, it improves sleep latency after 28 days1. Besides that, another combination containing
120mg hop extract and 500mg valerian root extract improves sleep latency after taking it for 28 days².
In a small clinical study comprising of healthy volunteers with poor sleep, it shows that taking a combination of 460mg hop extract and 460mg valerian root extract dissolved in 50ml honey water once nightly increases deep sleep duration and total sleep duration³.
Besides combining hop extract and valerian root extract, research also shows that combining hop extract with lemon balm and valerian⁴ or passionflower and valerian⁵ can help to improve sleep quality.
Anxiety, depression and stress
It is shown in a study that taking 400mg hop extract once daily for 4 weeks can help healthy young adults to significantly improve their symptoms of mild depression, anxiety and stress⁶.
Adverse effects
Hops are commonly consumed in foods and are generally well tolerated when used in food amounts, hop extract in supplemental amounts seems to be well tolerated as well. The most common adverse effects are drowsiness and sedation which explain its potential benefit in insomnia.
Dosage range
A typical dosing is unavailable due to limited research. However, dosages below are some of the used dosages in a few clinical studies.
Taken in combination with valerian root extract, at a dose of 83.8mg to 460mg once daily for about 28 days.
400mg hop extracts once daily for 4 weeks⁶.
Contraindications/cautions
Additive sedation can happen if there is concomitant use of CNS depressants such as barbiturates and benzodiazepines with hop extracts⁷.
Hop extracts might interfere with hormone replacement therapy if taken in high dose due to its competition for oestrogen receptors⁸.
Adverse effects
Hops are commonly consumed in foods and are generally well tolerated when used in food amounts, hop extract in supplemental amounts seems to be well tolerated as well. The most common adverse effects are drowsiness and sedation which explain its potential benefit in insomnia.
Dosage range
A typical dosing is unavailable due to limited research. However, dosages below are some of the used dosages in a few clinical studies.
Taken in combination with valerian root extract, at a dose of 83.8mg to 460mg once daily for about 28 days.
400mg hop extracts once daily for 4 weeks⁶.
Contraindications/cautions
Additive sedation can happen if there is concomitant use of CNS depressants such as barbiturates and benzodiazepines with hop extracts⁷.
Hop extracts might interfere with hormone replacement therapy if taken in high dose due to its competition for oestrogen receptors⁸.
References :
- Morin, C. M., Koetter, U., Bastien, C., Ware, J. C., & Wooten, V. (2005). Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep, 28(11), 1465–1471. https://doi.org/10.1093/sleep/28.11.1465
- Koetter, U., Schrader, E., Käufeler, R., & Brattström, A. (2007). A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytotherapy research : PTR, 21(9), 847–851. https://doi.org/10.1002/ptr.2167
- Dimpfel, W., & Suter, A. (2008). Sleep improving effects of a single dose administration of a valerian/hops fluid extract – a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms. European journal of medical research, 13(5), 200–204.
- Lindahl, O., & Lindwall, L. (1989). Double blind study of a valerian preparation. Pharmacology, biochemistry, and behavior, 32(4), 1065–1066. https://doi.org/10.1016/0091-3057(89)90082-8
- Maroo, N., Hazra, A., & Das, T. (2013). Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. Indian journal of pharmacology, 45(1), 34–39. https://doi.org/10.4103/0253-7613.106432
- Kyrou, I., Christou, A., Panagiotakos, D., Stefanaki, C., Skenderi, K., Katsana, K., & Tsigos, C. (2017). Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study. Hormones (Athens, Greece), 16(2), 171–180. https://doi.org/10.14310/horm.2002.1738
- Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., & Winterhoff, H. (2006). Sedating effects of Humulus lupulus L. extracts. Phytomedicine : international journal of phytotherapy and phytopharmacology, 13(8), 535–541. https://doi.org/10.1016/j.- phymed.2006.05.010
- Milligan, S. R., Kalita, J. C., Heyerick, A., Rong, H., De Cooman, L., & De Keukeleire, D. (1999). Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. The Journal of clinical endocrinology and metabolism, 84(6), 2249–2252. https://doi.org/10.1210/jcem.84.6.5887
References :
- Morin, C. M., Koetter, U., Bastien, C., Ware, J. C., & Wooten, V. (2005). Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep, 28(11), 1465–1471. https://doi.org/10.1093/sleep/28.11.1465
- Koetter, U., Schrader, E., Käufeler, R., & Brattström, A. (2007). A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytotherapy research : PTR, 21(9), 847–851. https://doi.org/10.1002/ptr.2167
- Dimpfel, W., & Suter, A. (2008). Sleep improving effects of a single dose administration of a valerian/hops fluid extract – a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms. European journal of medical research, 13(5), 200–204.
- Lindahl, O., & Lindwall, L. (1989). Double blind study of a valerian preparation. Pharmacology, biochemistry, and behavior, 32(4), 1065–1066. https://doi.org/10.1016/0091-3057(89)90082-8
- Maroo, N., Hazra, A., & Das, T. (2013). Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. Indian journal of pharmacology, 45(1), 34–39. https://doi.org/10.4103/0253-7613.106432
- Kyrou, I., Christou, A., Panagiotakos, D., Stefanaki, C., Skenderi, K., Katsana, K., & Tsigos, C. (2017). Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study. Hormones (Athens, Greece), 16(2), 171–180. https://doi.org/10.14310/horm.2002.1738
- Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., & Winterhoff, H. (2006). Sedating effects of Humulus lupulus L. extracts. Phytomedicine : international journal of phytotherapy and phytopharmacology, 13(8), 535–541. https://doi.org/10.1016/j.- phymed.2006.05.010
- Milligan, S. R., Kalita, J. C., Heyerick, A., Rong, H., De Cooman, L., & De Keukeleire, D. (1999). Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. The Journal of clinical endocrinology and metabolism, 84(6), 2249–2252. https://doi.org/10.1210/jcem.84.6.5887
The material is prepared for informational purposes only and should not be construed as a piece of personal medical advice. Owing to each person’s varying health needs, a physician should be consulted before acting on any information provided in this material. Although every effort is made to ensure that this material is accurate, it is compiled for internal use only and should not be considered definitive. Neither VitaHealth nor its employees, or information providers shall be responsible or liable for any errors, inaccuracies, or other defects in the information contained in this publication.
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