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Gastro-AD® Fermented soy peptide

Overview

Gastro-AD® is a food supplement based on non-GMO soy fermented by Lactobacillus strain L.delbrueckii, R-187 (commercially known as Rosell-187). Fermented soy is recognised as a healthy, nutritive ingredient, which has been part of Asian culture for thousands of years (e.g. miso, natto, soy sauce, etc.) and is associated with various health benefits. Gastro-AD® has an excellent track record of safety and effective use for managing symptoms of gastroesophageal reflux disease (GERD).

 

Key indications

Symptoms of GERD

GERD is characterised as the regurgitation or reflux of stomach acid back up into the esophagus from the stomach. This may cause a burning sensation in the chest also known as heartburn, chest pain, difficulty swallowing, and nausea. It is shown by studies on gastritis patients, taking Gastro-AD® 30 minutes before a meal for 30 days helps in rapid and long-lasting relief within 15 minutes or less¹,². Besides that, fermented soy improved some indicators of heartburn-related quality of life and may have potential benefits for reducing heartburn frequency over time³.

Gastritis

Gastro-AD® not only consists of fermented soy peptides but also a significant proportion of heat-inactivated Rosell 187 (R0187) strain of lactic acid bacteria. It is shown that R0187 may have a suppressive effect on interleukin 8, the inflammatory cytokine, in intestinal cells⁴. This may help with modulating the inflammation response in the mucosal microenvironment and preventing stomach ulcers.

Adverse effects

  • Gastro-AD® is generally well-tolerated
  • No known adverse effects were recorded

Dosage range

Gastro-AD® has been tested in several clinical studies, in approximately 600 subjects. It was shown to be tolerable for Gastro-AD® up to 15g per day for 30 days¹. Results show that it provides quick relief from ulcer symptoms including heartburn, pain, vomiting, and constipation.

 

Reduce GERD Symptoms:
2g to 5g of Gastro-AD®, 3 times daily, 30min before meals for 30 days¹,²

Contraindications/cautions

  • No known interaction was recorded with Gastro-AD® fermented soy peptide
  • Insufficient reliable information is available for pregnancy and lactation

Adverse effects

  • Gastro-AD® is generally well-tolerated
  • No known adverse effects were recorded

Dosage range

Gastro-AD® has been tested in several clinical studies, in approximately 600 subjects. It was shown to be tolerable for Gastro-AD® up to 15g per day for 30 days¹. Results show that it provides quick relief from ulcer symptoms including heartburn, pain, vomiting, and constipation.

 

Reduce GERD Symptoms:
2g to 5g of Gastro-AD®, 3 times daily, 30min before meals for 30 days¹,²

Contraindications/cautions

  • No known interaction was recorded with Gastro-AD® fermented soy peptide
  • Insufficient reliable information is available for pregnancy and lactation

References :

  1. Bogdanov, I. (1979). Gastropharm–a preparation for treatment of gastritis, gastric and duodenal ulcers. Khranitelna promishlenost.
  2. Hirata, Y. & Uchida, A. (2003) Clinical effects of GASTRO AD for gastritis patients. Japanese Journal of Medicine and Pharmaceutical Science, 49(4), 597-601.
  3. Fatani, A., Vaher, K., Rivero-Mendoza, D., Alabasi, K., & Dahl, W. J. (2020). Fermented soy supplementation improves indicators of quality of life: a randomized, placebo-controlled, double-blind trial in adults experiencing heartburn. BMC research notes, 13(1), 364. https://doi.org/10.1186/s13104-020-05205-z
  4. Wallace, T. D., Bradley, S., Buckley, N. D., & Green-Johnson, J. M. (2003). Interactions of lactic acid bacteria with human intestinal epithelial cells: effects on cytokine production. Journal of food protection, 66(3), 466–472. https://doi.org/10.4315/0362-028x-66.3.466

References :

  1. Bogdanov, I. (1979). Gastropharm–a preparation for treatment of gastritis, gastric and duodenal ulcers. Khranitelna promishlenost.
  2. Hirata, Y. & Uchida, A. (2003) Clinical effects of GASTRO AD for gastritis patients. Japanese Journal of Medicine and Pharmaceutical Science, 49(4), 597-601.
  3. Fatani, A., Vaher, K., Rivero-Mendoza, D., Alabasi, K., & Dahl, W. J. (2020). Fermented soy supplementation improves indicators of quality of life: a randomized, placebo-controlled, double-blind trial in adults experiencing heartburn. BMC research notes, 13(1), 364. https://doi.org/10.1186/s13104-020-05205-z
  4. Wallace, T. D., Bradley, S., Buckley, N. D., & Green-Johnson, J. M. (2003). Interactions of lactic acid bacteria with human intestinal epithelial cells: effects on cytokine production. Journal of food protection, 66(3), 466–472. https://doi.org/10.4315/0362-028x-66.3.466

The material is prepared for informational purposes only and should not be construed as a piece of personal medical advice. Owing to each person’s varying health needs, a physician should be consulted before acting on any information provided in this material. Although every effort is made to ensure that this material is accurate, it is compiled for internal use only and should not be considered definitive. Neither VitaHealth nor its employees, or information providers shall be responsible or liable for any errors, inaccuracies, or other defects in the information contained in this publication.

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