Product Fact Sheet

CHARGE-UP® NEURO PS

Formulated with advanced brain support ingredients for improving cognitive function. It enhances memory performance, energy level during stress, mood, focus and alertness in adults.

Each vegetable capsule contains:

Phosphatidylserine	500mcg
Acetyl-L-Carnitine HCl providing acetyl-L-carnitine 50mg	60.24mg
Vitamin B12 (methylcobalamin)	250mcg

Grape Seed Extract (Vitis vinifera) 100mg

100mg

providing 95% proanthocyanidins

Directions:

Adults – Take 1 vegetable capsule, twice daily, after meals or
as recommended by a doctor or pharmacist.

Why Choose VitaHealth CHARGE-UP® NEURO PS?

“Smart-pill” for adults – Nootropic supplement to boost brain function
Three ingredients work synergistically in enhancing cognitive function, especially in memory and brain energy levels
Phosphatidylserine (PS) and methylcobalamin work together in protecting nerve cells by stimulating the production of myelin. Myelin is an isolating layer that forms around nerves. It allows electrical impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, these impulses slow down
Improves memory – Acetyl-L-Carnitine (ALC) serves as the building block of acetylcholine while PS increases the production of acetylcholine in the brain. Acetylcholine is an important neurotransmitter that is involved in thinking and working memory
Non-stimulant type of nootropic supplement – Prevents brain fatigue in individuals with high stress levels
Maintains brain and nervous system function – Promotes the production of SAM-e by converting homocysteine to methionine. Methionine is the needed for the formation of SAM-e
US FDA approved health claim “Consumption of PS may reduce the risk of dementia in the elderly”
Vegan-friendly
Halal-certified

Benefits

Phosphatidylserine

Found in high amount in the brain
Improves brain memory, brain development and intelligence
Reduces and relieves stress and brain fatigue in individuals with work stress
Stimulates release of neurotransmitter
Optimises neural communication
Increases brain energy metabolism
Increases acetylcholine in the brain and hence improves rate of information transmission between brain nerve cells
Reduces oxidative stress in the brain
Decline of PS in neuronal membranes had been associated with memory impairment and deficits in mental cognitive abilities
PS causes structural neuronal changes (long-term) rather than transient metabolic changes (temporary). Beneficial effect might be maintained even after cessation of treatment

Acetyl-L-Carnitine HCl providing acetyl-L-carnitine

Enhances activity of nerve growth factor
Exerts neuroprotective effects
Reduces physical fatigue and mental fatigue
Slows rate of Alzheimer’s disease progression and improves memory
Anti-inflammatory effects, lead to stabilisation of membranes
Acts as an antioxidant protecting against oxidative stress
Serves as a precursor for acetylcholine, and be incorporated into neurotransmitters and lipids in the brain

Vitamin B12 (methylcobalamin)

Potent and active form of vitamin B12
Stored 13% more than cyanocobalamin in the liver
Exerts nerve cell protective effect
Promotes the production of myelin, which covers and protects nerve cells
Used as a cofactor in methionine transferase enzyme, an enzyme which converts homocysteine to
methionine via folate cycle. Methionine is required for the formation of S-adenosylmethionine (SAM-e), a universal methyl donor
SAM-e is essential to most biological methylation reactions including the myelin sheath production and the synthesis of neurotransmitters, for maintaining brain and nervous system function
Essential for cell growth, myelination, and function of the central nervous system, healthy red blood cell formation and DNA synthesis

Target Customers

Adults who wish to improve cognitive performance and thinking ability
Adults who are facing age-related decline in mental function
Adults who wish to stay focused in times of stress
University students who wish to improve memory and learning function

References :

Ferreira, G. C., & McKenna, M. C. (2017). l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain. Neurochemical Research, 42(6), 1661–1675.
Gröber, U., Kisters, K., & Schmidt, J. (2013). Neuroenhancement with Vitamin B12—Underestimated Neurological Significance. Nutrients, 5(12), 5031–5045.
Kato-Kataoka, A., Sakai, M., Ebina, R., Nonaka, C., Asano, T., & Miyamori, T. (2010). Soybean-derived Phosphatidylserine improves memory function of the elderly Japanese subjects with memory
complaints. Journal of Clinical Biochemistry and Nutrition, 47(3), 246-255.
Kobayashi, S., Iwamoto, M., Kon, K., Waki, H., Ando, S., & Tanaka, Y. (2010). Acetyl-l-carnitine improves aged brain function. Geriatrics & Gerontology International, 10, S99–S106,
Malaguarnera, M., Gargante, M. P., Cristaldi, E., Colonna, V., Messano, M., Koverech, A., Neri, S., Vacante, M., Cammalleri, L., & Motta, M. (2008). Acetyl l-carnitine (ALC) treatment in elderly patients with fatigue. Archives of Gerontology and Geriatrics, 46(2), 181–190.
Moré, M. I., Freitas, U., & Rutenberg, D. (2014). Positive effects of soy lecithin-derived Phosphatidylserine plus Phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer’s disease and dementia. Advances in Therapy, 31(12), 1247-1262.
National Institutes of Health. (2021, April 6). Office of Dietary Supplements – Vitamin B12. Vitamin B12 Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
Natural Medicines. (2021, January 15). Acetyl-L-Carnitine. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.as
px?productid=834
Paul, C., & Brady, D. M. (2017). Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms. Integrative Medicine, 16(1), 42–49.
Watson, R. R. (2017). Vitamin B12 Deficiency in the Elderly. In Nutrition and Functional Foods for Healthy Aging (pp. 159–166). Elsevier Gezondheidszorg.
Yong T, Quianyong Z, Mantian M, et al. (2011). Research on human memory enhancement by phosphatidylserine fortified milk. Chongqing Medicine. 30: 1671-83483.