Product Fact Sheet

Vitamins K2 + D3

Combines bioavailable ingredients − vitamin K2 in the form of menaquinone-7 (MK-7) and vitamin D3 to support bone and heart health as well as proper immune system function. Studies showed that vitamins K2 and D3 exert synergistic effects that are beneficial for the bone health.

Each vegetable capsule contains:

Vitamin K2	120mcg
Vitamin D3 (cholecalciferol)	1000IU

Grape Seed Extract (Vitis vinifera) 100mg

100mg

providing 95% proanthocyanidins

Directions:

Adults – Take 1 vegetable capsule, once daily, after a meal or as recommended by a doctor or pharmacist.

Why Choose VitaHealth Vitamins K2 + D3?

Tri-action supplement for the bones, heart and immune function
High strength vitamins K2 and D3
Vitamin K2 in the form of MK-7 showed 10x greater bioavailability compared to vitamin K1
Proven synergistic effect of vitamins K2 and D3 – Increases bones mass density (by 4.92% ± 7.89%)
More than just for bone health – Reduces risk of arterial stiffening and arterial calcification as well as proper immune system function. A study showed that dietary intake of vitamin K2 was associated with a 50% reduction in death from cardiovascular issues related to arterial calcification
Optimises calcium absorption and utilisation in the body with calcium-rich diet
Made in Canada

Benefits

Vitamin K2 (menaquinone-7)

Highest activity form of vitamin K2
Available for extrahepatic tissues such as bone and vasculature
Regulates the activity of osteocalcin and matrix GLA protein (MGP)
Activates osteocalcin that is needed for bone metabolism thus promotes bone strength and quality
Inhibits calcium from accumulating in the walls of artery by regulating MGP
Studies showed that adequate intake of vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening
Reduces the risk of cardiometabolic disease including cardiovascular disease, diabetes mellitus and chronic renal failure
Deficiency in vitamin K2 has been associated with unfavorable outcomes such as osteoporosis, hip fractures as well as cardiovascular disease
Recent study showed that insufficiency of extrahepatic vitamin K may lead to increased pulmonary damage and thrombosis risk

Vitamin D3 (cholecalciferol)

Recommended nutrient intake: 600IU for age of 19 – 70; 800IU for age of >70
Promotes calcium absorption in the gut and maintains adequate serum calcium concentration for normal bone mineralisation
Prevents hypocalcaemia tetany (involuntary contraction of muscles and leading to cramps and spasms)
Together with calcium, it helps protect elderly from osteoporosis
Deficiency in vitamin D is associated with osteomalacia (bone is incompletely or defectively mineralised during the remodelling process, resulting in weak bones) and increased autoimmunity as well as an increased susceptibility to infection

Target Customers

Menopausal women who are susceptible to osteoporosis
Men who are at high risk of cardiovascular disease
Individuals who are taking calcium supplements
Individuals who lead sedentary lifestyle
Individuals who have limited intake of foods that is rich in vitamin K2 such as milk, cheese and fermented foods
Individuals who are at risk of arterial calcification such as people with metabolic syndrome, dyslipidemia, tobacco use, hypertension, chronic kidney disease and high baseline C-reactive protein level

References :

Geleijnse, J. M., Vermeer, C., Grobbee, D. E., Schurgers, L. J., Knapen, M. H., Van der Meer, I. M., … Witteman, J. C. (2004). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam study. The Journal of Nutrition, 134(11), 3100-3105. doi:10.1093/jn/134.11.3100
Halder, M., Petsophonsakul, P., Akbulut, A., Pavlic, A., Bohan, F., Anderson, E., … Schurgers, L. (2019). Vitamin K: Double bonds beyond coagulation insights into differences between vitamin K1 and K2 in health and disease. International Journal of Molecular Sciences, 20(4), 896. doi:10.3390/ijms20040896
Janssen, R., Visser, M. P., Dofferhoff, A. S., Vermeer, C., Janssens, W., & Walk, J. (2020). Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in coronavirus
disease 2019. British Journal of Nutrition, 126(2), 191-198. doi:10.1017/s0007114520003979
Maresz, K. (2015). Proper Calcium Use: Vitamin K2 as a promoter of bone and cardiovascular health. Integrative Medicine, 14(1), 34-39
Martens, P., Gysemans, C., Verstuyf, A., & Mathieu, C. (2020). Vitamin D’s effect on immune function. Nutrients, 12(5), 1248. doi:10.3390/nu12051248
Sato, T., Inaba, N., & Yamashita, T. (2020). MK-7 and its effects on bone quality and strength. Nutrients, 12(4), 965. doi:10.3390/nu12040965
Sato, T., Schurgers, L. J., & Uenishi, K. (2012). Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutrition Journal, 11(1). doi:10.1186/1475-2891-11-93
Ushiroyama, T., Ikeda, A., & Ueki, M. (2002). Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas, 41(3), 211-221. doi:10.1016/s0378-5122(01)00275-4
Van Ballegooijen, A. J., Pilz, S., Tomaschitz, A., Grübler, M. R., & Verheyen, N. (2017). The synergistic interplay between vitamins D and K for bone and cardiovascular health: A narrative review. International Journal of Endocrinology, 2017, 1-12. doi:10.1155/2017/7454376
Vitamin D. (2021, March 23). Retrieved from https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/