Anti-inflammatory
Studies shown supplement with mixed berry-derived anthocyanidins isolates reduced levels of multiple proinflammatory chemokines (interleukin-8), regulated upon activation, normal T-cell expression and secretion, and interferon-alpha and cytokines (IL-4 and IL-13)³. Administration of bilberry singly or as part of dietary also shown to decrease serum levels of high-sensitivity C-reactive protein (hsCRP), IL-6, IL-12, IL-15, lipopolysaccharide, E-selectin, monokine induced by IFN-gamma⁸⁻⁷. The possible mechanism of action on anti-inflammatory activities of bilberry could be explained by the inhibition activation of nuclear factor-kappa B⁶,⁸.